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Tadarise 20 mg works by blocking the enzyme phosphodiesterase type 5 (PDE5). Normally, this enzyme breaks down cyclic guanosine monophosphate (cGMP), a chemical responsible for relaxing smooth muscles in blood vessels. When PDE5 is blocked, cGMP levels remain higher, allowing better blood flow into the penile tissues during sexual arousal, which helps achieve and maintain an erection.